Publications

Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

PLoS One. 2015; 10: e0116504

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren M, Boe AE, Murphy SB, Place AT,  Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GS, Mutlu GM, Miyata T, Vaughan DE.

Proc Natl Acad Sci USA. 2014; 111: 7090-7095.

Drug discovery in renal disease —towards a more efficient framework

Miyata T, Ando T, Hiragi H, Watanabe K, Yamamoto F, Vaughan DE, Kurokawa T, Oshima Y, van Ypersele de Strihou C, Takeuchi M.
Nature Review Nephrology. 2014; 10: 290-296.

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model

of diabetes.

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.

Diabetologia. 2014; 57: 224-235.

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration

Ibrahim AA, Yahata T, Onizuka M, Dan T, van Ypersele de Strihou C, Miyata T, Ando K.

Stem Cells. 2014; 32: 946-958.

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence

Boe A, Eren M, Murphy S, Kamide1 C, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE.
Circulation. 2013; 128: 2318-24.

Kidney failure: aims for the next 10 years and barriers to success

Remuzzi G, Benigni A, Finkelstein FO, Grunfeld JP, Joly D, Katz I, Liu ZH, Miyata T, Perico N, Rodriguez-Iturbe B, Antiga L, Schaefer F, Schieppati A, Schrier RW, Tonelli M.

Lancet　2013; 382: 353-362.

Diabetic nephropathy: Are there new and potentially promising therapies targeting oxygen biology?

Miyata T, Suzuki N, van Ypersele de Strihou C.

Kidney Int 2013; 84: 693-702.

A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou C, Miyata T.

Arterioscler Thromb Vasc Biol. 2013; 33: 935-942.

Metabolic stress response implicated in diabetic retinopathy:the role of calpain, and the therapeutic impact of calpain inhibitor.

Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Takaomi S, Minegishi N, Miyata T, Abe T, Yamamoto M.

Neurobiology of Disease 2012; 48: 556-567.

The receptor of advanced glycation end products (RAGE) plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J.

Kidney Int 2012; 82 759-770

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.

Blood 2012; 119: 6382-6393.

Protection against methylglyoxal-derived AGEs by regulation of glyoxalse-1 prevents retinal neuroglial and vasodegenerative pathology.

Berner AK, Brouwers O, Pringle R, Klaassen I, Colhoun L, McVicar C, Brockbank S, Curry JW, Miyata T, Brownlee M, Schlingemann RO, Schalkwijk C, Stitt AW.

Diabetologia 2012; 55: 845-854. 

Skin advanced glycation end product accumulation is negatively associated with calcaneal osteo-sono assessment index among non-diabetic adult Japanese men.
Momma H, Niu K, Kobayashi Y, Guan L, Sato M, Guo H, Chujo M, Otomo A, Yufei C, Tadaura H, Saito T, Mori T, Miyata T, Nagatomi R.

Osteoporos Int 2012; 23: 1673-1681.

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.

Huang WT, Vayalil PK, Miyata T, Hagood J, Liu RM.

Am J Respir Cell Mol Biol. 2012; 46: 87-95.

Glyoxalase-I retards renal senescence.

Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.

Am J Pathol 2011; 179: 2810-2821.

New era for drug discovery and development in renal disease.

   Miyata T, Kikuchi K, Kiyomoyo H,van Ypersele de Strihou C.

   Nat Rev Nephrol 2011;7:469-477.

In Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Renal Disorders (Springer), edited by Toshio MIyata, Kai-Uwe Eckardt, Masaomi Nangaku.

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets.

Miyata T, Takizawa S,van Ypersele de Strihou C.

Am J Physiol Cell Physiol 2011;300:226-231.

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients.

Kakuta T, Tanaka R, Hyodo T, Suzuki H, Kanai G, Nagaoka M, Takahashi H, Hirawa N, Oogushi Y, Miyata T, Kobayashi H, Fukagawa M, Saito A.

Am J Kidney Dis 2011;57:422-431.

Overexpression of Glyoxalase-I Reduces Hyperglycemia–induced Levels of Advanced Glycation Endproducts and Oxidative Stress in Diabetic Rats.

Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T, Schrauwen P, Brownlee M, Stehouwer CD, Schalkwijk CG. 

J Bio Chem. 2011 ;286:1374-1380.

Enhanced carbonyl stress in a subpopulation of schizophrenia.

Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A,Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.  

Arch Gen Psychiatry 2010; 67: 589-597.

Diabetic nephropathy: a disorder of oxygen metabolism?

Miyata T, van Ypersele de Strihou C.

Nat Rev Nephrol. 2010;6:83-95.